Written by: Dr. Terrie Van Alstyne, ND
Understanding Pregnenolone and Its Role in Hormone Production
As women approach perimenopause and menopause, the levels of steroid hormones, including estrogen (E1, E2, E3), progesterone, testosterone, DHEA, cortisol, growth hormone, and pregnenolone, typically decline. Pregnenolone, produced in the adrenal gland, plays a crucial role in synthesizing these hormones. By increasing other sex hormone levels, pregnenolone can help mitigate menopausal symptoms and reduce age-related mortality risks, such as Alzheimer’s disease, osteoporosis, cardiovascular disease, and breast cancer.
Factors Affecting Pregnenolone Levels
A high-stress lifestyle can elevate cortisol levels, leading to pregnenolone depletion. Other factors contributing to low pregnenolone levels include:
Diet high in saturated or trans fats
Hypothyroidism (low thyroid function)
Low cholesterol levels
Symptoms of Low Pregnenolone
Low levels of pregnenolone can lead to various symptoms, including:
Low morning energy
Poor memory
Declining concentration and attention
Fatigue
Dry skin
Joint and muscle pain
Loss of bone density
Insomnia
Hot flashes and night sweats
Vaginal dryness
Decreased sex drive
Benefits of Pregnenolone in Hormone Therapy
Pregnenolone positively impacts mood, memory, and sleep. It inhibits cortisol production, making it an effective stress reducer. Additionally, pregnenolone has immunosuppressive effects that limit tissue damage and chronic inflammation associated with chronic and autoimmune diseases.
Dietary Considerations for Boosting Pregnenolone
To support pregnenolone production, it's essential to consume healthy fats. Foods such as:
Avocados
Coconut oil
Olive oil
Walnuts
Fish
Chia seeds
Flax seeds
These foods provide the body with the cholesterol needed to synthesize pregnenolone and other hormones.
Testing for Pregnenolone Levels
A comprehensive blood hormone panel should include pregnenolone levels. This test can be requested through a medical or naturopathic doctor to determine if hormone therapy is necessary.
Conclusion: The Importance of Pregnenolone in Hormone Therapy
For women experiencing menopausal symptoms, understanding and managing pregnenolone levels can be crucial for overall health and well-being. By considering lifestyle factors, dietary choices, and hormone testing, women can optimize their hormone therapy and improve their quality of life.
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