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Writer's pictureTerrie Van Alstyne

Pregnenolone: A Hormone Not to Be Missed in Hormone Therapy (HT)

Updated: Oct 18

Written by: Dr. Terrie Van Alstyne, ND


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Understanding Pregnenolone and Its Role in Hormone Production

As women approach perimenopause and menopause, the levels of steroid hormones, including estrogen (E1, E2, E3), progesterone, testosterone, DHEA, cortisol, growth hormone, and pregnenolone, typically decline. Pregnenolone, produced in the adrenal gland, plays a crucial role in synthesizing these hormones. By increasing other sex hormone levels, pregnenolone can help mitigate menopausal symptoms and reduce age-related mortality risks, such as Alzheimer’s disease, osteoporosis, cardiovascular disease, and breast cancer.


Factors Affecting Pregnenolone Levels

A high-stress lifestyle can elevate cortisol levels, leading to pregnenolone depletion. Other factors contributing to low pregnenolone levels include:

  • Diet high in saturated or trans fats

  • Hypothyroidism (low thyroid function)

  • Low cholesterol levels


Symptoms of Low Pregnenolone

Low levels of pregnenolone can lead to various symptoms, including:

  • Low morning energy

  • Poor memory

  • Declining concentration and attention

  • Fatigue

  • Dry skin

  • Joint and muscle pain

  • Loss of bone density

  • Insomnia

  • Hot flashes and night sweats

  • Vaginal dryness

  • Decreased sex drive


Benefits of Pregnenolone in Hormone Therapy

Pregnenolone positively impacts mood, memory, and sleep. It inhibits cortisol production, making it an effective stress reducer. Additionally, pregnenolone has immunosuppressive effects that limit tissue damage and chronic inflammation associated with chronic and autoimmune diseases.


Dietary Considerations for Boosting Pregnenolone

To support pregnenolone production, it's essential to consume healthy fats. Foods such as:

  • Avocados

  • Coconut oil

  • Olive oil

  • Walnuts

  • Fish

  • Chia seeds

  • Flax seeds

These foods provide the body with the cholesterol needed to synthesize pregnenolone and other hormones.


Testing for Pregnenolone Levels

A comprehensive blood hormone panel should include pregnenolone levels. This test can be requested through a medical or naturopathic doctor to determine if hormone therapy is necessary.


Conclusion: The Importance of Pregnenolone in Hormone Therapy

For women experiencing menopausal symptoms, understanding and managing pregnenolone levels can be crucial for overall health and well-being. By considering lifestyle factors, dietary choices, and hormone testing, women can optimize their hormone therapy and improve their quality of life.


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